Trazodone (Desyrel) is an antidepressant of the serotonin antagonist and reuptake inhibitor class. It is a phenylpiperazine compound. Trazodone also has anti-anxiety and sleep-inducing effects. Its side-effect profile and potential toxicity are considerably different from those of the original antidepressants (i.e., the monoamine oxidase inhibitors and tricyclic antidepressants). It is available in multiple generic and brand versions. Generic trazodone is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
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Those with depression may begin to notice improvement in symptoms in 1-2 weeks, but in may take 4-6 weeks before the maximum benefit is reached. Some symptoms may improve before others do, and you may have good days and bad days for a few weeks - this is normal progress when recovering from depression.
Therapy is usually started at a total of 150 mg per day divided into two or three doses. This dose is increased by 50 mg every three or four days until the desired effects are seen. Daily doses may be increased to a maximum of 400 mg per day in outpatients and up to 600 mg per day in hospitalized patients. In cases of extreme depression, daily doses of up to 800 mg have been used in hospitalized patients.
Amitriptyline is a prescription drug that's used to treat depression. It's sometimes known by its former brand name, Elavil, but its manufacturer, AstraZeneca, stopped making it. Amitriptyline is only available as a generic drug in the United States. Besides depression, amitriptyline can be used "off-label" to treat post-herpetic neuralgia, attention deficit hyperactivity disorder, and certain eating disorders. It may also be used to prevent symptoms of migraines. It is in the tricyclic antidepressant class and its exact mechanism of action is unclear. Amitriptyline is taken by mouth.
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In depression it may take between 1 to 4 weeks before amitriptyline starts to work and you begin to feel better. Usually recommend continuing antidepressants for at least six months after recovery. With nerve pain amitriptyline may start to help in a few days for some people, while others don't see much difference for 1-2 weeks.
Usual adult dose for depression: 75 mg orally per day in divided doses; this may be increased to a total of 150 mg per day if needed.
Alternate dose: 40 to 100 mg orally as a single dose at bedtime; this may be increased by 25 or 50 mg as needed at bedtime to a total of 150 mg per day.
Maximum dose: 150 mg orally per day.
Questions & Answers
You can not buy trazodone and amitriptyline without prescription in the US, Canada, UK and most other countries in the world. You need to get a prescription for antidepressants from your doctor before being able to access the meds. If you have a prescription, Walgreens, CVS, Walmart or any other online pharmacy will sell drugs for you.
I was prescribed trazadone to help me sleep which it does but it has also helped me tremendously with my depression. This has been good for me. I am having a problem with interaction with Zoloft effecting my eyes. I am going to talk to my doctor about changing my antidepressant.
Trazodone works great for me. I actually only take 50 mg. And get a good 7-8 hours sleep. I'm a diagnosed insomniac. But Trazodone does the job.
I was taking regular Trazodone on and off for a couple of years, it stopped working so my doctor switched me to Desyrel. It's a good pill for the fact that it does make you tired, but I'd make sure you're gonna get 8 or more hours of sleep before you take it. I was prescribed 100mg pills, and I only took half of a pill whenever I took it, and I had the hardest time waking up the next day. Also, with the reg Trazodone and with Desyrel, it took a long time for it to kick in for me (2 hours), but that might be because I have a high tolerance to pills. If you're new to this medicine, take it on the weekend, or whenever you can sleep in, so you can see how it works.
I wasn't prescribed 10mg of amitriptyline for migraines and to help me sleep. This drug is great for helping you sleep. I was drowsy within 10 mins of taking it at night before bed. However, as a migraine prophylactic it did not help. I had migraines occurring frequently and often worse than they were prior to starting this medication. I also gained 18 lbs in 4 months. My breasts became very swollen and tender and I ended up extremely depressed. My dosage was the lowest you can get. I cannot even imagine taking more than I did and the side effects it would have had. I don't recommend this to anyone.
I have had insomia for months. Dr started me on Elavil 10mg for sleep, within a half hour I'm a sleep. I have not slept this good in a long time. I am not a zombie either in the mornings. I feel very good when I awake. Best thing.
If I take amitriptyline in the morning, I am so tired that functioning and performing even small tasks is very difficult. But if I take it too late at night, I have really bad nightmares. So find a time that works best for you.