Onglyza vs Metformin


  • Onglyza
  • What is Onglyza

    Onglyza (saxagliptin) is an oral diabetes drugs that helps control blood sugar levels. It works by regulating the levels of insulin your body produces after eating. Saxagliptin is for people with type 2 diabetes. Onglyza is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes.

  • Onglyza price

    $ 124.95 (5mg x 28 pills)

    prices from H&B Pharmacy

  • How does onglyza work

    Onglyza is a daily diabetes medication in the class known as gliptins (DPP-4 inhibitors).

    These medicines help to control blood glucose levels by increasing the amount of insulin released by the pancreas and decreasing the body's release of glucagon.

    Saxagliptin is used alone or alongside other oral diabetes drugs.

    These may include metformin, sulfonylurea or a thiazolidinedione.

    Morning blood sugar can rise when you're sleeping, due to the pancreas releasing too much glucagon, which makes the liver release too much sugar. Onglyza (saxagliptin) reduces the amount of sugar released by your liver overnight, which may result in lower blood sugar.

    After-meal blood sugar spikes can occur when your pancreas doesn't release enough insulin or your body's cells do not use insulin properly. Onglyza (saxagliptin) may lower after-meal blood sugar spikes by helping your body increase levels of insulin after meals.

  • How to take onglyza (dosage)

    The usual dose of this medicine is one pill taken once a day. The pills should be swallowed whole and not split or cut.

    The pill can be taken either with or without food at any time of the day. Try to always take your pills at the same time of day, as this will help you remember to take it.

    If you forget to take a dose at your usual time you should take it as soon as you remember. However, if this means taking two doses in one day you should skip the missed dose and continue as normal. Don't take two doses in one day.

  • Side effects

    • Headache;
    • Bloating;
    • Runny or stuffy nose;
    • Sore throat, cough, hoarseness;
    • Nausea, stomach pain, vomiting, or diarrhea;
    • Severe pain in your upper stomach that spreads to your back;
    • Fast heart rate;
    • Painful urination;
    • Swelling of the hands, ankles, or feet;
    • Easy bleeding or bruising;
    • Purple or red skin rash that spreads and causes blistering, or swelling of the face, lips, tongue, or throat.


  • Metformin
  • What is Metformin

    Metformin (Glucophage Xr) is an inexpensive medicine used to treat high blood sugar levels caused by type 2 diabetes. It is is more popular than comparable drugs. It is available in both brand and generic versions. Generic metformin is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

  • Metformin price

    $ 30.00 (500mg x 30 pills)

    prices from H&B Pharmacy

  • How does metformin work

    Metformin works in a number of ways to lower blood sugar levels in people with type 2 diabetes.

    1. It increases the sensitivity of muscle cells to insulin. This enables these cells to remove sugar from the blood more effectively.
    2. In every human body, the liver releases small amounts of glucose throughout the day. The primary effect of taking metformin is that this release of glucose from the liver is lessened, resulting in lower blood sugars.
    3. It delays the absorption of sugar from the intestines into the bloodstream after eating so that there is less of a spike in blood sugar levels after meals.

    Patients also tend to see their cholesterol levels drop and an increase in sensitivity to insulin. Some metformin users lose weight because of the drug's affect on appetite, naturally leading the patient to eat fewer calories!

  • How to take metformin (dosage)

    For the first week of treatment you will usually be asked to take 500mg metformin once a day.

    After this, your dose may be gradually increased, either by taking the medicine two and then three times a day, or by taking higher strength tablets. It's important that you always follow the instructions given by your doctor. These will be printed on the dispensing label that your pharmacist has put on the medicine. If you are unsure about anything, ask your doctor or pharmacist for advice.

    All forms of metformin should be taken with a meal or a snack.

  • Side effects

    • Bloating, constipation;
    • Stomach pain, heartburn;
    • Indigestion, diarrhea;
    • Headache, dizziness;
    • Unpleasant metallic taste in your mouth;
    • Nail changes;
    • Muscle or chest pain;
    • Extreme tiredness;
    • Fast or slow heartbeat;
    • Flushing of the skin or a rash;
    • Feeling cold;
    • Decreased appetite;
    • Deep or rapid breathing or shortness of breath.

Questions & Answers

Where to buy onglyza or metformin over the counter in the U.S.?

You can not buy onglyza and metformin without prescription in the US, Canada, UK and most other countries in the world. You need to get a prescription for diabetes pills from your doctor before being able to access the meds. If you have a prescription, Walgreens, CVS, Walmart or any other online pharmacy will sell drugs for you.



I'm currently taking Onglyza for my type 2 diabetes once a day. My levels have not really decreased. I am still in the range of 7.5 to 8... My diet is right on target and so are my exercise routines... I can't inject or test monitor/lancet. I am not going to continue to increase my pill intake by another pill form medication. What does one do?


Blood glucose was well within acceptable ranges for 4-6 weeks, after that they began to graduaolly increase. The whole time I have been taking this I have had multiple (6-8 times a day) incidences of complete whole body drenching sweating. This is enough to cause be to seek another drugs. I will call the dr seeking an alternative medication.


I'm taking Onglyza with Lantus. It took about two weeks for the headache to do away but other than that, it's great and no side effects except one for which I'm grateful. All the weight put on by the Lantus (117 lbs) is starting to come off slowly but steadily.


Been taking 1000 mg twice a day for almost 9 years along with Lantus. Metformin messed with my stomach, etc., for about 2-3 weeks, but no adverse events since then.


I love Metformin - oral contraceptives never helped me and only Metformin has been able to help control my PCOS symptoms. It took about 6 months for me to see any real benefits and then I noticed that the benefits were incredible. I have lost a lot of weight, and I just wanted to offer a word of caution. Please continue to go to your doctor and monitor your progress. Metformin (although I love it) is a pretty serious drug with major side effects. As you lose weight, your dose may need adjusting as mine did. I went from 2000mg a day to years ago down to 500 over those two years!


I had some initial weight loss from metformin. I think it was in part due to having diarrhea initally, a slightly diminshed appetite and a sort of metallic taste. All those side effects went away though.

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