Onglyza vs Glipizide


  • Onglyza
  • What is Onglyza

    Onglyza (saxagliptin) is an oral diabetes drugs that helps control blood sugar levels. It works by regulating the levels of insulin your body produces after eating. Saxagliptin is for people with type 2 diabetes. Onglyza is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes.

  • Onglyza price

    $ 124.95 (5mg x 28 pills)

    prices from H&B Pharmacy

  • How does onglyza work

    Onglyza is a daily diabetes medication in the class known as gliptins (DPP-4 inhibitors).

    These medicines help to control blood glucose levels by increasing the amount of insulin released by the pancreas and decreasing the body's release of glucagon.

    Saxagliptin is used alone or alongside other oral diabetes drugs.

    These may include metformin, sulfonylurea or a thiazolidinedione.

    Morning blood sugar can rise when you're sleeping, due to the pancreas releasing too much glucagon, which makes the liver release too much sugar. Onglyza (saxagliptin) reduces the amount of sugar released by your liver overnight, which may result in lower blood sugar.

    After-meal blood sugar spikes can occur when your pancreas doesn't release enough insulin or your body's cells do not use insulin properly. Onglyza (saxagliptin) may lower after-meal blood sugar spikes by helping your body increase levels of insulin after meals.

  • How to take onglyza (dosage)

    The usual dose of this medicine is one pill taken once a day. The pills should be swallowed whole and not split or cut.

    The pill can be taken either with or without food at any time of the day. Try to always take your pills at the same time of day, as this will help you remember to take it.

    If you forget to take a dose at your usual time you should take it as soon as you remember. However, if this means taking two doses in one day you should skip the missed dose and continue as normal. Don't take two doses in one day.

  • Side effects

    • Headache;
    • Bloating;
    • Runny or stuffy nose;
    • Sore throat, cough, hoarseness;
    • Nausea, stomach pain, vomiting, or diarrhea;
    • Severe pain in your upper stomach that spreads to your back;
    • Fast heart rate;
    • Painful urination;
    • Swelling of the hands, ankles, or feet;
    • Easy bleeding or bruising;
    • Purple or red skin rash that spreads and causes blistering, or swelling of the face, lips, tongue, or throat.


  • Glipizide
  • What is Glipizide

    Glipizide (Glucotrol) is a prescription meds that's used along with diet and exercise, and sometimes with other medications, to reduce blood sugar levels in people with high blood sugar caused by type 2 diabetes. It's available in oral immediate-release tablet, oral extended-release tablet and generic form. Generic drugs usually cost less.

  • Glipizide price

    $ 20.00 (5mg x 30 pills)

    prices from H&B Pharmacy

  • How does glipizide work

    Glipizide works mainly by stimulating the cells in the pancreas that produce insulin. These cells are called beta cells. Glipizide causes the beta cells to produce more insulin. This helps to decrease the amount of sugar in the blood of people with type 2 diabetes.

    Glipizide also increases the uptake of sugar from the blood into muscle and fat cells and decreases the production of sugar by the liver.

    Glipizide is a first line option for treating type 2 diabetes in people who are not overweight, or who cannot take metformin. It is used when diet and exercise have failed to control blood sugar levels. It can also be used in combination with other antidiabetic medicines to provide better control of blood sugar.

    Many medications may affect how well glipizide works, change your blood sugar levels, or increase your risk of side effects. To be safe, tell your pharmacist or doctor about everything you take: prescription and over-the-counter medicines, vitamins, and herbs. They are the experts who can help you prevent or minimize drug interactions by adjusting your medications or doses as needed.

  • How to take glipizide (dosage)

    The regular Glipizide tablet is usually taken one or more times a day, 30 minutes before breakfast or meals. The extended-release tablet is usually taken once a day with breakfast. Take glucotrol exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

    Your doctor will probably start you on a low dose of glipizide and gradually increase your dose if needed. After you have taken glucotrol for some time, glucotrol may not control your blood sugar as well as it did at the beginning of your treatment. Your doctor may adjust the dose of your medication as needed so that the medication will work best for you. Be sure to tell your doctor how you are feeling and if your blood sugar test results have been higher or lower than normal at any time during your treatment.

  • Side effects

    • Diarrhea;
    • Dizziness;
    • Red or itchy skin;
    • Uncontrollable shaking;
    • Dark urine;
    • Light-colored stools;
    • Yellowing of the eyes or skin;
    • Mental or mood changes;
    • Fever, sore throat;
    • Pain in the upper right area of the stomach;
    • Unusual bleeding or bruising;
    • Unusual or sudden weight gain;
    • Extreme mental or mood changes;
    • Swelling of the eyes, face, lips, tongue, or throat.

Questions & Answers

Where to buy onglyza or glipizide over the counter in the U.S.?

You can not buy onglyza and glipizide without prescription in the US, Canada, UK and most other countries in the world. You need to get a prescription for diabetes pills from your doctor before being able to access the meds. If you have a prescription, Walgreens, CVS, Walmart or any other online pharmacy will sell drugs for you.



I'm currently taking Onglyza for my type 2 diabetes once a day. My levels have not really decreased. I am still in the range of 7.5 to 8... My diet is right on target and so are my exercise routines... I can't inject or test monitor/lancet. I am not going to continue to increase my pill intake by another pill form medication. What does one do?


Blood glucose was well within acceptable ranges for 4-6 weeks, after that they began to graduaolly increase. The whole time I have been taking this I have had multiple (6-8 times a day) incidences of complete whole body drenching sweating. This is enough to cause be to seek another drugs. I will call the dr seeking an alternative medication.


I'm taking Onglyza with Lantus. It took about two weeks for the headache to do away but other than that, it's great and no side effects except one for which I'm grateful. All the weight put on by the Lantus (117 lbs) is starting to come off slowly but steadily.

Denzel H.

I could not take metformin so my doctor gave me glipizide and it worked great and I'm still at 5mg once a day. No problems, no weight gain, no high sugar problems.

Adam C.

I have taken glipizide for years with no problems then in December 2016 I was in the hospital low sodium level (danger zone) vomiting stomach pain the doctor said maybe the glipizide he took me off the pill but now I can not keep my sugar level under control without it.

Loni Q

I have used Glucotrol for about 5 years now as a secondary medicine. Glipizide helps to keep my blood sugar numbers within range and keeps me from having to use insulin as much as I would without it, which is a good thing. I haven't had any side effects from the glipizide at all. I'm very happy with this medication.

Add review