Onglyza vs Actos


  • Onglyza
  • What is Onglyza

    Onglyza (saxagliptin) is an oral diabetes drugs that helps control blood sugar levels. It works by regulating the levels of insulin your body produces after eating. Saxagliptin is for people with type 2 diabetes. Onglyza is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes.

  • Onglyza price

    $ 124.95 (5mg x 28 pills)

    prices from H&B Pharmacy

  • How does onglyza work

    Onglyza is a daily diabetes medication in the class known as gliptins (DPP-4 inhibitors).

    These medicines help to control blood glucose levels by increasing the amount of insulin released by the pancreas and decreasing the body's release of glucagon.

    Saxagliptin is used alone or alongside other oral diabetes drugs.

    These may include metformin, sulfonylurea or a thiazolidinedione.

    Morning blood sugar can rise when you're sleeping, due to the pancreas releasing too much glucagon, which makes the liver release too much sugar. Onglyza (saxagliptin) reduces the amount of sugar released by your liver overnight, which may result in lower blood sugar.

    After-meal blood sugar spikes can occur when your pancreas doesn't release enough insulin or your body's cells do not use insulin properly. Onglyza (saxagliptin) may lower after-meal blood sugar spikes by helping your body increase levels of insulin after meals.

  • How to take onglyza (dosage)

    The usual dose of this medicine is one pill taken once a day. The pills should be swallowed whole and not split or cut.

    The pill can be taken either with or without food at any time of the day. Try to always take your pills at the same time of day, as this will help you remember to take it.

    If you forget to take a dose at your usual time you should take it as soon as you remember. However, if this means taking two doses in one day you should skip the missed dose and continue as normal. Don't take two doses in one day.

  • Side effects

    • Headache;
    • Bloating;
    • Runny or stuffy nose;
    • Sore throat, cough, hoarseness;
    • Nausea, stomach pain, vomiting, or diarrhea;
    • Severe pain in your upper stomach that spreads to your back;
    • Fast heart rate;
    • Painful urination;
    • Swelling of the hands, ankles, or feet;
    • Easy bleeding or bruising;
    • Purple or red skin rash that spreads and causes blistering, or swelling of the face, lips, tongue, or throat.


  • Actos
  • What is Actos

    Actos (Pioglitazone Hydrochloride) is one of six types of diabetes pills currently used to treat type 2 diabetes. It will help keep your blood glucose levels within your target range by making your body more sensitive to insulin. It is not for use in treatment of Type 1 diabetes or diabetic ketoacidosis. Actos Is available as a generic drug. You need a prescription for Actos.

  • Actos price

    $ 44.95 (15mg x 30 pills)

    prices from H&B Pharmacy

  • How does actos work

    • Actos improves how the body uses insulin.
    • Actos decreases the amount of glucose released by the liver.
    • Actos does not cause the body to make more insulin, therefore, when used alone, it does not cause low blood glucose (hypoglycemia).

    Guidelines for use:

    • Actos can be taken with or without food.
    • Some medications similar to Actos have caused liver problems. Although Actos has not been associated with liver problems, your healthcare provider will check your liver function prior to your using the medication and then every two months for the first year.
    • To further improve your blood glucose control, your healthcare provider may have you use Actos in combination with another diabetes pill or with insulin.

  • How to take actos (dosage)

    Actos comes as a tablet and is typically taken by mouth once a day, with or without meals.

    Your dosage will be based on your medical condition, response to treatment, and other drugs you're taking.

    Try to take pioglitazone around the same time each day.

    Your doctor might start you on a low dose and gradually increase it.

    Follow the instructions on your prescription label carefully. Don't take more or less than is prescribed.

  • Side effects

    • Headache;
    • Sore throat;
    • Gas;
    • Sinus pain;
    • Stomach pain, loss of appetite;
    • Swelling or rapid weight gain;
    • Tooth problems;
    • Pain in the arms or legs;
    • Vision changes or vision loss;
    • Discolored, cloudy, or bloody urine;
    • Back or abdominal pain;
    • Feeling short of breath, even with mild exertion.

Questions & Answers

Where to buy onglyza or actos over the counter in the U.S.?

You can not buy onglyza and actos without prescription in the US, Canada, UK and most other countries in the world. You need to get a prescription for diabetes pills from your doctor before being able to access the meds. If you have a prescription, Walgreens, CVS, Walmart or any other online pharmacy will sell drugs for you.



I'm currently taking Onglyza for my type 2 diabetes once a day. My levels have not really decreased. I am still in the range of 7.5 to 8... My diet is right on target and so are my exercise routines... I can't inject or test monitor/lancet. I am not going to continue to increase my pill intake by another pill form medication. What does one do?


Blood glucose was well within acceptable ranges for 4-6 weeks, after that they began to graduaolly increase. The whole time I have been taking this I have had multiple (6-8 times a day) incidences of complete whole body drenching sweating. This is enough to cause be to seek another drugs. I will call the dr seeking an alternative medication.


I'm taking Onglyza with Lantus. It took about two weeks for the headache to do away but other than that, it's great and no side effects except one for which I'm grateful. All the weight put on by the Lantus (117 lbs) is starting to come off slowly but steadily.


I don't care what the FDA said when they put this drug back on the market... I have spoken to many oncologists in major hospitals and they have no doubt that 4 years of Actos caused my bladder cancer. Shame on the FDA for giving in to pressure once again.


I was on actos for about 6 months and experienced unexplained fatigue, weight gain, fluid retention, shortness of breath and (the last straw that broke the camel's back) Congestive Heart Failure-CHF in Dec '15. Then when I reported the CHF to my Endocrinologist on Jan 9 she said it was the actos and immediately took me off (the actos). I'm humbly advising all and sundry to stay away from this drug for it will damage you slowly.

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