Metformin vs Actos


  • Metformin
  • What is Metformin

    Metformin (Glucophage Xr) is an inexpensive medicine used to treat high blood sugar levels caused by type 2 diabetes. It is is more popular than comparable drugs. It is available in both brand and generic versions. Generic metformin is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

  • Metformin price

    $ 30.00 (500mg x 30 pills)

    prices from H&B Pharmacy

  • How does metformin work

    Metformin works in a number of ways to lower blood sugar levels in people with type 2 diabetes.

    1. It increases the sensitivity of muscle cells to insulin. This enables these cells to remove sugar from the blood more effectively.
    2. In every human body, the liver releases small amounts of glucose throughout the day. The primary effect of taking metformin is that this release of glucose from the liver is lessened, resulting in lower blood sugars.
    3. It delays the absorption of sugar from the intestines into the bloodstream after eating so that there is less of a spike in blood sugar levels after meals.

    Patients also tend to see their cholesterol levels drop and an increase in sensitivity to insulin. Some metformin users lose weight because of the drug's affect on appetite, naturally leading the patient to eat fewer calories!

  • How to take metformin (dosage)

    For the first week of treatment you will usually be asked to take 500mg metformin once a day.

    After this, your dose may be gradually increased, either by taking the medicine two and then three times a day, or by taking higher strength tablets. It's important that you always follow the instructions given by your doctor. These will be printed on the dispensing label that your pharmacist has put on the medicine. If you are unsure about anything, ask your doctor or pharmacist for advice.

    All forms of metformin should be taken with a meal or a snack.

  • Side effects

    • Bloating, constipation;
    • Stomach pain, heartburn;
    • Indigestion, diarrhea;
    • Headache, dizziness;
    • Unpleasant metallic taste in your mouth;
    • Nail changes;
    • Muscle or chest pain;
    • Extreme tiredness;
    • Fast or slow heartbeat;
    • Flushing of the skin or a rash;
    • Feeling cold;
    • Decreased appetite;
    • Deep or rapid breathing or shortness of breath.


  • Actos
  • What is Actos

    Actos (Pioglitazone Hydrochloride) is one of six types of diabetes pills currently used to treat type 2 diabetes. It will help keep your blood glucose levels within your target range by making your body more sensitive to insulin. It is not for use in treatment of Type 1 diabetes or diabetic ketoacidosis. Actos Is available as a generic drug. You need a prescription for Actos.

  • Actos price

    $ 44.95 (15mg x 30 pills)

    prices from H&B Pharmacy

  • How does actos work

    • Actos improves how the body uses insulin.
    • Actos decreases the amount of glucose released by the liver.
    • Actos does not cause the body to make more insulin, therefore, when used alone, it does not cause low blood glucose (hypoglycemia).

    Guidelines for use:

    • Actos can be taken with or without food.
    • Some medications similar to Actos have caused liver problems. Although Actos has not been associated with liver problems, your healthcare provider will check your liver function prior to your using the medication and then every two months for the first year.
    • To further improve your blood glucose control, your healthcare provider may have you use Actos in combination with another diabetes pill or with insulin.

  • How to take actos (dosage)

    Actos comes as a tablet and is typically taken by mouth once a day, with or without meals.

    Your dosage will be based on your medical condition, response to treatment, and other drugs you're taking.

    Try to take pioglitazone around the same time each day.

    Your doctor might start you on a low dose and gradually increase it.

    Follow the instructions on your prescription label carefully. Don't take more or less than is prescribed.

  • Side effects

    • Headache;
    • Sore throat;
    • Gas;
    • Sinus pain;
    • Stomach pain, loss of appetite;
    • Swelling or rapid weight gain;
    • Tooth problems;
    • Pain in the arms or legs;
    • Vision changes or vision loss;
    • Discolored, cloudy, or bloody urine;
    • Back or abdominal pain;
    • Feeling short of breath, even with mild exertion.

Questions & Answers

Where to buy metformin or actos over the counter in the U.S.?

You can not buy metformin and actos without prescription in the US, Canada, UK and most other countries in the world. You need to get a prescription for diabetes pills from your doctor before being able to access the meds. If you have a prescription, Walgreens, CVS, Walmart or any other online pharmacy will sell drugs for you.



Been taking 1000 mg twice a day for almost 9 years along with Lantus. Metformin messed with my stomach, etc., for about 2-3 weeks, but no adverse events since then.


I love Metformin - oral contraceptives never helped me and only Metformin has been able to help control my PCOS symptoms. It took about 6 months for me to see any real benefits and then I noticed that the benefits were incredible. I have lost a lot of weight, and I just wanted to offer a word of caution. Please continue to go to your doctor and monitor your progress. Metformin (although I love it) is a pretty serious drug with major side effects. As you lose weight, your dose may need adjusting as mine did. I went from 2000mg a day to years ago down to 500 over those two years!


I had some initial weight loss from metformin. I think it was in part due to having diarrhea initally, a slightly diminshed appetite and a sort of metallic taste. All those side effects went away though.


I don't care what the FDA said when they put this drug back on the market... I have spoken to many oncologists in major hospitals and they have no doubt that 4 years of Actos caused my bladder cancer. Shame on the FDA for giving in to pressure once again.


I was on actos for about 6 months and experienced unexplained fatigue, weight gain, fluid retention, shortness of breath and (the last straw that broke the camel's back) Congestive Heart Failure-CHF in Dec '15. Then when I reported the CHF to my Endocrinologist on Jan 9 she said it was the actos and immediately took me off (the actos). I'm humbly advising all and sundry to stay away from this drug for it will damage you slowly.

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