Januvia vs Metformin


  • Januvia
  • What is Januvia

    Januvia (Sitagliptin Phosphate) is a once-daily prescription tablet that, along with diet and exercise, helps lower blood sugar levels in adults with type 2 diabetes. Januvia should not be used in patients with type 1 diabetes or with diabetic ketoacidosis. If you have had pancreatitis, it is not known if you have a higher chance of getting it while taking Januvia.

  • Januvia price

    $ 59.95 (25mg x 14 pills)

    prices from H&B Pharmacy

  • How does januvia work

    Januvia works by increasing the amount of two incretin hormones found in the body, called glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). These hormones are normally produced naturally by the body in response to food intake. Their function is to help control blood sugar levels.

    GLP-1 and GIP have 4 main actions that help to control blood glucose:

    1. They stimulate the pancreas to produce insulin in response to increasing levels of glucose in the blood.
    2. GLP-1 also reduces the production of glucagon.
    3. GLP-1 and GIP reduce the rate at which food passes from the stomach into the intestines, which slows down the absorption of glucose from the gut into the bloodstream.
    4. They act on the brain to cause a feeling of fullness that reduces further food intake.

  • How to take januvia (dosage)

    Take Januvia only when prescribed by your doctor. The recommended dose is to take: one 100 mg pill (once a day) by mouth, with or without food.

    If you have kidney problems, your doctor may prescribe lower doses, and monitor your kidney function.

    Your doctor may prescribe Januvia on its own, or with certain other medicines that lower blood sugar.

    Follow all directions given to you by your pharmacist or doctor carefully. If you do not understand the instructions on the box, ask your pharmacist or doctor for help.

  • Side effects

    • Back pain;
    • Constipation;
    • Diarrhea;
    • Headache;
    • Joint or muscle pain;
    • Little or no urination;
    • Nausea;
    • Severe joint pain;
    • Shortness of breath;
    • Sore throat;
    • Stomach pain;
    • Stuffy or runny nose;
    • Weight gain.


  • Metformin
  • What is Metformin

    Metformin (Glucophage Xr) is an inexpensive medicine used to treat high blood sugar levels caused by type 2 diabetes. It is is more popular than comparable drugs. It is available in both brand and generic versions. Generic metformin is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

  • Metformin price

    $ 30.00 (500mg x 30 pills)

    prices from H&B Pharmacy

  • How does metformin work

    Metformin works in a number of ways to lower blood sugar levels in people with type 2 diabetes.

    1. It increases the sensitivity of muscle cells to insulin. This enables these cells to remove sugar from the blood more effectively.
    2. In every human body, the liver releases small amounts of glucose throughout the day. The primary effect of taking metformin is that this release of glucose from the liver is lessened, resulting in lower blood sugars.
    3. It delays the absorption of sugar from the intestines into the bloodstream after eating so that there is less of a spike in blood sugar levels after meals.

    Patients also tend to see their cholesterol levels drop and an increase in sensitivity to insulin. Some metformin users lose weight because of the drug's affect on appetite, naturally leading the patient to eat fewer calories!

  • How to take metformin (dosage)

    For the first week of treatment you will usually be asked to take 500mg metformin once a day.

    After this, your dose may be gradually increased, either by taking the medicine two and then three times a day, or by taking higher strength tablets. It's important that you always follow the instructions given by your doctor. These will be printed on the dispensing label that your pharmacist has put on the medicine. If you are unsure about anything, ask your doctor or pharmacist for advice.

    All forms of metformin should be taken with a meal or a snack.

  • Side effects

    • Bloating, constipation;
    • Stomach pain, heartburn;
    • Indigestion, diarrhea;
    • Headache, dizziness;
    • Unpleasant metallic taste in your mouth;
    • Nail changes;
    • Muscle or chest pain;
    • Extreme tiredness;
    • Fast or slow heartbeat;
    • Flushing of the skin or a rash;
    • Feeling cold;
    • Decreased appetite;
    • Deep or rapid breathing or shortness of breath.

Questions & Answers

Where to buy januvia or metformin over the counter in the U.S.?

You can not buy januvia and metformin without prescription in the US, Canada, UK and most other countries in the world. You need to get a prescription for diabetes pills from your doctor before being able to access the meds. If you have a prescription, Walgreens, CVS, Walmart or any other online pharmacy will sell drugs for you.



I am a chronic pain patient as well as a type two diabetic, so I don't really know if it's the Januvia or my back causing this, but since taking it, my feet feel like they are frozen in blocks of ice, yet they are not really cold. I'm wearing 3 heavy pairs of socks yet they are still cold "feeling".


I used Januvia for a month and a half. It worked well at first. Then my right knee swelled, my left foot I could not walk on. When I stopped taking Januvia swelling went away. It worked well at controlling my blood sugar levels, but too much pain. Oh... I never injured my knee or foot.


Been taking 1000 mg twice a day for almost 9 years along with Lantus. Metformin messed with my stomach, etc., for about 2-3 weeks, but no adverse events since then.


I love Metformin - oral contraceptives never helped me and only Metformin has been able to help control my PCOS symptoms. It took about 6 months for me to see any real benefits and then I noticed that the benefits were incredible. I have lost a lot of weight, and I just wanted to offer a word of caution. Please continue to go to your doctor and monitor your progress. Metformin (although I love it) is a pretty serious drug with major side effects. As you lose weight, your dose may need adjusting as mine did. I went from 2000mg a day to years ago down to 500 over those two years!


I had some initial weight loss from metformin. I think it was in part due to having diarrhea initally, a slightly diminshed appetite and a sort of metallic taste. All those side effects went away though.

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