Glipizide vs Actos


  • Glipizide
  • What is Glipizide

    Glipizide (Glucotrol) is a prescription meds that's used along with diet and exercise, and sometimes with other medications, to reduce blood sugar levels in people with high blood sugar caused by type 2 diabetes. It's available in oral immediate-release tablet, oral extended-release tablet and generic form. Generic drugs usually cost less.

  • Glipizide price

    $ 20.00 (5mg x 30 pills)

    prices from H&B Pharmacy

  • How does glipizide work

    Glipizide works mainly by stimulating the cells in the pancreas that produce insulin. These cells are called beta cells. Glipizide causes the beta cells to produce more insulin. This helps to decrease the amount of sugar in the blood of people with type 2 diabetes.

    Glipizide also increases the uptake of sugar from the blood into muscle and fat cells and decreases the production of sugar by the liver.

    Glipizide is a first line option for treating type 2 diabetes in people who are not overweight, or who cannot take metformin. It is used when diet and exercise have failed to control blood sugar levels. It can also be used in combination with other antidiabetic medicines to provide better control of blood sugar.

    Many medications may affect how well glipizide works, change your blood sugar levels, or increase your risk of side effects. To be safe, tell your pharmacist or doctor about everything you take: prescription and over-the-counter medicines, vitamins, and herbs. They are the experts who can help you prevent or minimize drug interactions by adjusting your medications or doses as needed.

  • How to take glipizide (dosage)

    The regular Glipizide tablet is usually taken one or more times a day, 30 minutes before breakfast or meals. The extended-release tablet is usually taken once a day with breakfast. Take glucotrol exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

    Your doctor will probably start you on a low dose of glipizide and gradually increase your dose if needed. After you have taken glucotrol for some time, glucotrol may not control your blood sugar as well as it did at the beginning of your treatment. Your doctor may adjust the dose of your medication as needed so that the medication will work best for you. Be sure to tell your doctor how you are feeling and if your blood sugar test results have been higher or lower than normal at any time during your treatment.

  • Side effects

    • Diarrhea;
    • Dizziness;
    • Red or itchy skin;
    • Uncontrollable shaking;
    • Dark urine;
    • Light-colored stools;
    • Yellowing of the eyes or skin;
    • Mental or mood changes;
    • Fever, sore throat;
    • Pain in the upper right area of the stomach;
    • Unusual bleeding or bruising;
    • Unusual or sudden weight gain;
    • Extreme mental or mood changes;
    • Swelling of the eyes, face, lips, tongue, or throat.


  • Actos
  • What is Actos

    Actos (Pioglitazone Hydrochloride) is one of six types of diabetes pills currently used to treat type 2 diabetes. It will help keep your blood glucose levels within your target range by making your body more sensitive to insulin. It is not for use in treatment of Type 1 diabetes or diabetic ketoacidosis. Actos Is available as a generic drug. You need a prescription for Actos.

  • Actos price

    $ 44.95 (15mg x 30 pills)

    prices from H&B Pharmacy

  • How does actos work

    • Actos improves how the body uses insulin.
    • Actos decreases the amount of glucose released by the liver.
    • Actos does not cause the body to make more insulin, therefore, when used alone, it does not cause low blood glucose (hypoglycemia).

    Guidelines for use:

    • Actos can be taken with or without food.
    • Some medications similar to Actos have caused liver problems. Although Actos has not been associated with liver problems, your healthcare provider will check your liver function prior to your using the medication and then every two months for the first year.
    • To further improve your blood glucose control, your healthcare provider may have you use Actos in combination with another diabetes pill or with insulin.

  • How to take actos (dosage)

    Actos comes as a tablet and is typically taken by mouth once a day, with or without meals.

    Your dosage will be based on your medical condition, response to treatment, and other drugs you're taking.

    Try to take pioglitazone around the same time each day.

    Your doctor might start you on a low dose and gradually increase it.

    Follow the instructions on your prescription label carefully. Don't take more or less than is prescribed.

  • Side effects

    • Headache;
    • Sore throat;
    • Gas;
    • Sinus pain;
    • Stomach pain, loss of appetite;
    • Swelling or rapid weight gain;
    • Tooth problems;
    • Pain in the arms or legs;
    • Vision changes or vision loss;
    • Discolored, cloudy, or bloody urine;
    • Back or abdominal pain;
    • Feeling short of breath, even with mild exertion.

Questions & Answers

Where to buy glipizide or actos over the counter in the U.S.?

You can not buy glipizide and actos without prescription in the US, Canada, UK and most other countries in the world. You need to get a prescription for diabetes pills from your doctor before being able to access the meds. If you have a prescription, Walgreens, CVS, Walmart or any other online pharmacy will sell drugs for you.


Denzel H.

I could not take metformin so my doctor gave me glipizide and it worked great and I'm still at 5mg once a day. No problems, no weight gain, no high sugar problems.

Adam C.

I have taken glipizide for years with no problems then in December 2016 I was in the hospital low sodium level (danger zone) vomiting stomach pain the doctor said maybe the glipizide he took me off the pill but now I can not keep my sugar level under control without it.

Loni Q

I have used Glucotrol for about 5 years now as a secondary medicine. Glipizide helps to keep my blood sugar numbers within range and keeps me from having to use insulin as much as I would without it, which is a good thing. I haven't had any side effects from the glipizide at all. I'm very happy with this medication.


I don't care what the FDA said when they put this drug back on the market... I have spoken to many oncologists in major hospitals and they have no doubt that 4 years of Actos caused my bladder cancer. Shame on the FDA for giving in to pressure once again.


I was on actos for about 6 months and experienced unexplained fatigue, weight gain, fluid retention, shortness of breath and (the last straw that broke the camel's back) Congestive Heart Failure-CHF in Dec '15. Then when I reported the CHF to my Endocrinologist on Jan 9 she said it was the actos and immediately took me off (the actos). I'm humbly advising all and sundry to stay away from this drug for it will damage you slowly.

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