Flexeril vs Skelaxin


  • Flexeril
  • What is Flexeril

    Flexeril (Cyclobenzaprine) is a muscle relaxer that relieves pain and discomfort caused by strains, sprains, and other muscle injuries. It has also been used off-label for fibromyalgia treatment.

  • Flexeril price

    $ 29.95 (Package 15mg x 10 pills)

    prices from H&B Pharmacy

  • How long does it take for flexeril to work

    This medication begins working within 20-30 minutes after it is ingested.

  • How does flexeril work

    Flexeril works by increasing the release of the chemical norepinephrine from central nervous structures in the brain. Cyclobenzaprine acting on the central nervous system, blocking nerve impulses that are sent from sore muscles to your brain.

  • Flexeril dosage

    The regular pills dosage is 2-4 times a day, while the extended release capsule is generally taken 1-2 times a day. The usual starting dose, according to the Drug Enforcement Administration, is 5 mg three times a day. The maximum recommended dose is 10 mg three times a day.

  • Side effects

    • dry mouth;
    • fatigue, weakness;
    • upset stomach;
    • loss of appetite;
    • dizziness, headaches;
    • drowsiness;
    • pounding heartbeat;
    • confusion with weakness and lack of coordination.


  • Skelaxin
  • What is Skelaxin

    Skelaxin (Metaxalone) is a prescription pills. Skelaxin belongs to a group of drugs called muscle relaxants. It is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.

  • Skelaxin price

    $ 19.95 (Package 400mg x 10 pills)

    prices from H&B Pharmacy

  • How long does it take for skelaxin to work

    It should begin working to relieve your symptoms right away (approximately 1 hour).

  • How does skelaxin work

    The exact mechanism of action of Skelaxin is unknown, but it may be due to general central nervous system depression. Metaxalone is presumed to work by blocking transmission of nerve impulses in the brain thus relieving pain sensations.

  • Skelaxin dosage

    Skelaxin comes in an 800 mg tablet and is usually taken 3 to 4 times a day. You should not take more than 800 mg of metaxalone more than 4 times a day. Skelaxin pills are best taken on an empty stomach or with a small snack. Taking tablets with food can increase the effects.

  • Side effects

    • drowsiness;
    • headache, dizziness;
    • nervousness, irritability;
    • rash, allergic reactions;
    • jaundice;
    • anemia;
    • nausea, vomiting, upset stomach;
    • low white blood cell count.



I have degenerative disc disease and this medication helps. It does not make me drowsy like some other muscle relaxers. It isn't quite as dramatic in it's effect but the alternative is worse; like taking Flexeril and having to sleep! Skelaxin works about the same if not a little better but is really expensive so I am glad this much less expensive alternate works for me. This medication allows me to function and receive some moderate relief.

John F

Prescribed Cyclobenzaprine 10mg for a short trial period to assist with relaxing undetermined back muscular pain. I would take it in the evening, and Cyclobenzaprine did help me relax, but did little for the pain. Weird though... every single instance, I would get a good night of sleep, but just be bitchy/moody/on edge the entire next day.


I've had Flexeril prescribed for back pain for many years now. It really work for me. The main side effect is drowsiness. Makes me really sleepy. For that reason, I take it before bedtime.


I have had back spasms that come out of nowhere at times, that literally drop me to my knees. I can't take vicodin & don't really like taking any habit forming drugs. My physician gave me Skelaxin & upon taking the first dosage, I felt my muscles relax. I wasn't drowsy from it either. The only side effect was I had a headache the first day or two. It was prescribed for only short term usage. I would recommend this product if asked.


I have some intermittent problems with severe neck and shoulder spasms, and Skelaxin works very well for me.

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