Nortriptyline is a second-generation tricyclic antidepressant marketed as the hydrochloride salt under the trade names Aventyl and Pamelor. It is used in the treatment of major depression and childhood nocturnal enuresis. Its off-label uses include treatment of chronic fatigue syndrome, chronic pain and migraine, and labile affect in some neurological disorders. It may also be used to help people quit smoking and to treat attention deficit hyperactivity disorder. Nortriptyline comes as a capsule and an oral liquid to take by mouth.
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Every patient is different. You may notice some initial benefit within 2 weeks, however it may take up to 2 months for a full effect. Your doctor may need to increase the dose to get the maximum effect. If you do not feel any improvement in your pain after 2 months, do not suddenly stop taking the tablets but speak to your doctor.
Usual adult dose - 25 mg three or four times daily; dosage should begin at a low level and be increased as required. As an alternative regimen, the total daily dosage may be given once a day. When doses above 100 mg daily are administered, plasma levels of nortriptyline should be monitored and maintained in the optimum range of 50 to 150 ng/mL. Doses above 150 mg/day are not recommended.
Zoloft is the brand name of sertraline, an antidepressant used to treat major depressive disorders (post traumatic stress disorder, panic disorder, obsessive compulsive disorder, social anxiety disorder and premenstrual dysphoric disorder). Zoloft is in a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). They work by controlling levels of serotonin in the brain. Zoloft relieves symptoms of depression without the side effects that many people experience with the older tricyclic antidepressants and MAO inhibitors.
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Although some symptoms (sleep, energy or appetite) may improve within a matter of days, it is important to allow four to six or even eight weeks for the medication to be fully effective. If no improvement is seen in two to four weeks, another medication can be tried.
Zoloft is administered once daily by mouth in the morning or evening:
Nortriptyline has helped with my constant headache and has also helped me cope with my stress/anxiety. I'm on a low dose (20mg/day) and take at night. The first week I was out cold within minutes of taking the medication. That affect has worn off, but I continue to sleep well and wake up refreshed.
This med is amazing. I've had peripheral Neuropathy for a few years in my feet. I've tried Gabapentin, it didn't work. I tried Nortriptyline, I've been on it for 3-4 weeks...it's amazing... NO pins/needles feeling, no burning sensation! I still have some pressure in my feet, but things are so different now! I'm going to give it more time, but I think I found my holy grail! I understand it may not work for everyone, but so far it's working for me. If you are looking for something, ask your doctor and try it, it might work for you. Good luck to all of you!
I'm 45 years old and have been on Zoloft for 20 years. I have slowly weaned myself off the drug over the last 12 months. It has now been 2 months without the drug. I am totally debilitated by brain fog, loss of memory, lack of concentration, and irritability. Can anyone please help me with might be happening to me or has anyone been through similar experiences to mine? I'm so upset everyday.... thanks!
I was on Zoloft for about 8 years for severe generalized anxiety disorder and major depressive disorder. I was eventually maxed out (200mg) and I felt awful. I couldn't feel emotions at all, it was almost like depression but less hopeless. I felt like a zombie. Or a robot. I also had pretty severe sexual side effects as well. Got taken off, and I feel like a real human again. I'm on Wellbutrin now.
I was prescribed zoloft in the past and it worked well, so my doctor thought that we should try it again for my anxiety and depression. it worked very well in a short amount of time. it was worth the night sweats to have normal days.