Nortriptyline is a second-generation tricyclic antidepressant marketed as the hydrochloride salt under the trade names Aventyl and Pamelor. It is used in the treatment of major depression and childhood nocturnal enuresis. Its off-label uses include treatment of chronic fatigue syndrome, chronic pain and migraine, and labile affect in some neurological disorders. It may also be used to help people quit smoking and to treat attention deficit hyperactivity disorder. Nortriptyline comes as a capsule and an oral liquid to take by mouth.
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Every patient is different. You may notice some initial benefit within 2 weeks, however it may take up to 2 months for a full effect. Your doctor may need to increase the dose to get the maximum effect. If you do not feel any improvement in your pain after 2 months, do not suddenly stop taking the tablets but speak to your doctor.
Usual adult dose - 25 mg three or four times daily; dosage should begin at a low level and be increased as required. As an alternative regimen, the total daily dosage may be given once a day. When doses above 100 mg daily are administered, plasma levels of nortriptyline should be monitored and maintained in the optimum range of 50 to 150 ng/mL. Doses above 150 mg/day are not recommended.
Trazodone (Desyrel) is an antidepressant of the serotonin antagonist and reuptake inhibitor class. It is a phenylpiperazine compound. Trazodone also has anti-anxiety and sleep-inducing effects. Its side-effect profile and potential toxicity are considerably different from those of the original antidepressants (i.e., the monoamine oxidase inhibitors and tricyclic antidepressants). It is available in multiple generic and brand versions. Generic trazodone is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
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Those with depression may begin to notice improvement in symptoms in 1-2 weeks, but in may take 4-6 weeks before the maximum benefit is reached. Some symptoms may improve before others do, and you may have good days and bad days for a few weeks - this is normal progress when recovering from depression.
Therapy is usually started at a total of 150 mg per day divided into two or three doses. This dose is increased by 50 mg every three or four days until the desired effects are seen. Daily doses may be increased to a maximum of 400 mg per day in outpatients and up to 600 mg per day in hospitalized patients. In cases of extreme depression, daily doses of up to 800 mg have been used in hospitalized patients.
Nortriptyline has helped with my constant headache and has also helped me cope with my stress/anxiety. I'm on a low dose (20mg/day) and take at night. The first week I was out cold within minutes of taking the medication. That affect has worn off, but I continue to sleep well and wake up refreshed.
This med is amazing. I've had peripheral Neuropathy for a few years in my feet. I've tried Gabapentin, it didn't work. I tried Nortriptyline, I've been on it for 3-4 weeks...it's amazing... NO pins/needles feeling, no burning sensation! I still have some pressure in my feet, but things are so different now! I'm going to give it more time, but I think I found my holy grail! I understand it may not work for everyone, but so far it's working for me. If you are looking for something, ask your doctor and try it, it might work for you. Good luck to all of you!
I was prescribed trazadone to help me sleep which it does but it has also helped me tremendously with my depression. This has been good for me. I am having a problem with interaction with Zoloft effecting my eyes. I am going to talk to my doctor about changing my antidepressant.
Trazodone works great for me. I actually only take 50 mg. And get a good 7-8 hours sleep. I'm a diagnosed insomniac. But Trazodone does the job.
I was taking regular Trazodone on and off for a couple of years, it stopped working so my doctor switched me to Desyrel. It's a good pill for the fact that it does make you tired, but I'd make sure you're gonna get 8 or more hours of sleep before you take it. I was prescribed 100mg pills, and I only took half of a pill whenever I took it, and I had the hardest time waking up the next day. Also, with the reg Trazodone and with Desyrel, it took a long time for it to kick in for me (2 hours), but that might be because I have a high tolerance to pills. If you're new to this medicine, take it on the weekend, or whenever you can sleep in, so you can see how it works.