Maxalt (Rizatriptan) is a prescription medication used to treat migraine headaches once they have started. Rizatriptan belongs to a group of drugs called serotonin receptor agonists or "triptans", which relieve pain by narrowing blood vessels around the brain.
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Maxalt works by stimulating receptors called serotonin (or 5HT) receptors that are found in the brain. A natural substance called serotonin normally acts on these receptors, causing blood vessels in the brain to narrow. Maxalt mimics this action of serotonin by directly stimulating the serotonin receptors in the brain. This narrows the blood vessels and so relieves the pain of migraine headaches.
The half-life of maxalt is 2 to 3 hours, so after 8, at least 80% of it would be out of your system.
The recommended adult starting dose of maxalt is 5 mg. In some cases, a starting dose of 10 mg may be used. The dose should be taken at the first sign of migraine headache pain. If the migraine headache comes back after being relieved, another dose (5 mg to 10 mg) may be taken no sooner than 2 hours after the first dose was taken.
The maximum recommended single dose is 10 mg. No more than 20 mg of maxalt should be taken in any 24-hour period. If your headache pain is different from your usual migraines, do not take maxalt and call your doctor. Maxalt is not to be used for headache prevention.
Topamax (Topiramate) is a prescription medication used to treat certain types of seizures in adults and children. It is also used to prevent migraines in patients 12 years of age and older. Topiramate belongs to a group of drugs called anticonvulsants, which decrease abnormal brain activity.
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Topamax affects the activity of two neurotransmitters (natural chemicals that are involved in transmitting messages between the nerve cells) in the brain. Topamax enhances the action of GABA and decreases the action of glutamate. Topamax also works by preventing sodium from entering the nerve cells when they begin to fire rapid and repetitive electrical signals. This prevents the electrical signal from building up and passing on. All three actions help prevent fits.
The half-life of Topamax is reported at 21 hours. This is the time for 1/2 of the amount in the body to be eliminated. Typically - physicians use a period of time equal to 5 or 6 half-lives as a measure of when a drug has cleared. In that case you are in the 4-6 days range.
Topamax is available in tablets (25 mg, 50 mg, 100 mg, and 200 mg) that can be taken orally.
Those who take Topamax typically start with a low dose of 25 or 50 mg per day (divided over two doses), increasing it slowly by 25 to 50 mg per week until an effective daily dose is reached.
Migraine patients are usually given 25 mg every night for the first week, with the dose being increased by 25 mg weekly. The maximum dose is 100 mg, to be taken in two divided doses.
Maxalt is a very good migraine medicine for me. No side effects but only a little tired but that's good.
I suffered from frequent migraines, complete with nausea, for nearly 15 years. Around 2-4 times a month. Tried everything, thought nothing would help. Then tried Maxalt (Rizatriptan)! (Similar to Imitrex). It really works - for me at least. If you haven't tried Imitrex or Maxalt, you really should. Only side effect is being slightly tired.
I was taking Topamax a few years ago for Migraines. I must say I really did lose weight while taking Topamax and I felt great. After taking it about 3 months I noticed that I was becoming depressed. After doing some reading on my insurance carries website, I found that depression is a side effect of Topamax, otherwise it would have been great for me. If you don't have any problems GREAT because it WORKS VERY WELL!
I have been I topamax for 9 weeks and been taking 50 mg daily at night... at the begining of the treatment it did help me prevent the migraines but now it does not. By the time I get up, I wake up with a headache, so am afraid I need to go and see the the dr again.