Januvia (Sitagliptin Phosphate) is a once-daily prescription tablet that, along with diet and exercise, helps lower blood sugar levels in adults with type 2 diabetes. Januvia should not be used in patients with type 1 diabetes or with diabetic ketoacidosis. If you have had pancreatitis, it is not known if you have a higher chance of getting it while taking Januvia.
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Januvia works by increasing the amount of two incretin hormones found in the body, called glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). These hormones are normally produced naturally by the body in response to food intake. Their function is to help control blood sugar levels.
GLP-1 and GIP have 4 main actions that help to control blood glucose:
Take Januvia only when prescribed by your doctor. The recommended dose is to take: one 100 mg pill (once a day) by mouth, with or without food.
If you have kidney problems, your doctor may prescribe lower doses, and monitor your kidney function.
Your doctor may prescribe Januvia on its own, or with certain other medicines that lower blood sugar.
Follow all directions given to you by your pharmacist or doctor carefully. If you do not understand the instructions on the box, ask your pharmacist or doctor for help.
Glipizide (Glucotrol) is a prescription meds that's used along with diet and exercise, and sometimes with other medications, to reduce blood sugar levels in people with high blood sugar caused by type 2 diabetes. It's available in oral immediate-release tablet, oral extended-release tablet and generic form. Generic drugs usually cost less.
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Glipizide works mainly by stimulating the cells in the pancreas that produce insulin. These cells are called beta cells. Glipizide causes the beta cells to produce more insulin. This helps to decrease the amount of sugar in the blood of people with type 2 diabetes.
Glipizide also increases the uptake of sugar from the blood into muscle and fat cells and decreases the production of sugar by the liver.
Glipizide is a first line option for treating type 2 diabetes in people who are not overweight, or who cannot take metformin. It is used when diet and exercise have failed to control blood sugar levels. It can also be used in combination with other antidiabetic medicines to provide better control of blood sugar.
Many medications may affect how well glipizide works, change your blood sugar levels, or increase your risk of side effects. To be safe, tell your pharmacist or doctor about everything you take: prescription and over-the-counter medicines, vitamins, and herbs. They are the experts who can help you prevent or minimize drug interactions by adjusting your medications or doses as needed.
The regular Glipizide tablet is usually taken one or more times a day, 30 minutes before breakfast or meals. The extended-release tablet is usually taken once a day with breakfast. Take glucotrol exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Your doctor will probably start you on a low dose of glipizide and gradually increase your dose if needed. After you have taken glucotrol for some time, glucotrol may not control your blood sugar as well as it did at the beginning of your treatment. Your doctor may adjust the dose of your medication as needed so that the medication will work best for you. Be sure to tell your doctor how you are feeling and if your blood sugar test results have been higher or lower than normal at any time during your treatment.
I am a chronic pain patient as well as a type two diabetic, so I don't really know if it's the Januvia or my back causing this, but since taking it, my feet feel like they are frozen in blocks of ice, yet they are not really cold. I'm wearing 3 heavy pairs of socks yet they are still cold "feeling".
I used Januvia for a month and a half. It worked well at first. Then my right knee swelled, my left foot I could not walk on. When I stopped taking Januvia swelling went away. It worked well at controlling my blood sugar levels, but too much pain. Oh... I never injured my knee or foot.
I could not take metformin so my doctor gave me glipizide and it worked great and I'm still at 5mg once a day. No problems, no weight gain, no high sugar problems.
I have taken glipizide for years with no problems then in December 2016 I was in the hospital low sodium level (danger zone) vomiting stomach pain the doctor said maybe the glipizide he took me off the pill but now I can not keep my sugar level under control without it.
I have used Glucotrol for about 5 years now as a secondary medicine. Glipizide helps to keep my blood sugar numbers within range and keeps me from having to use insulin as much as I would without it, which is a good thing. I haven't had any side effects from the glipizide at all. I'm very happy with this medication.