Imitrex (Sumatriptan) is a prescription medication used to treat migraine headaches once they have started. Sumatriptan belongs to a group of drugs called serotonin receptor agonists or "triptans", which relieve pain by narrowing blood vessels around the brain.
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Imitrex acts on serotonin (or 5HT) receptors that are found on blood vessels in the brain, causing them to narrow. It's also thought to inhibit the action of the trigeminal nerve. These actions relieve the headache and other symptoms that you may get with your migraine, such as feeling sick or sensitivity to light or sound.
The half life is 1,5-2,6 hours. It takes about 7,5-15,6 hours for Imitrex to clear out of the system.
The recommended dose of Imitrex in tablet form is: 25 mg, 50 mg or 100 mg.
Your doctor will prescribe the right dose for you.
After the first recommended dose, you may be advised to take a second dose two hours or more later, if your migraine has not resolved. The maximum daily dose of Imitrex tablets is 200 mg in a 24-hour time period.
An additional dose of the injection can also be given if the first dose does not work and 2 hours or more have passed.
Topamax (Topiramate) is a prescription medication used to treat certain types of seizures in adults and children. It is also used to prevent migraines in patients 12 years of age and older. Topiramate belongs to a group of drugs called anticonvulsants, which decrease abnormal brain activity.
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Topamax affects the activity of two neurotransmitters (natural chemicals that are involved in transmitting messages between the nerve cells) in the brain. Topamax enhances the action of GABA and decreases the action of glutamate. Topamax also works by preventing sodium from entering the nerve cells when they begin to fire rapid and repetitive electrical signals. This prevents the electrical signal from building up and passing on. All three actions help prevent fits.
The half-life of Topamax is reported at 21 hours. This is the time for 1/2 of the amount in the body to be eliminated. Typically - physicians use a period of time equal to 5 or 6 half-lives as a measure of when a drug has cleared. In that case you are in the 4-6 days range.
Topamax is available in tablets (25 mg, 50 mg, 100 mg, and 200 mg) that can be taken orally.
Those who take Topamax typically start with a low dose of 25 or 50 mg per day (divided over two doses), increasing it slowly by 25 to 50 mg per week until an effective daily dose is reached.
Migraine patients are usually given 25 mg every night for the first week, with the dose being increased by 25 mg weekly. The maximum dose is 100 mg, to be taken in two divided doses.
Imitrex changed my life. I only take 50 mg the best part about is that after the migraine wears off the medication give me a lift of energy. Wish I had this sooner I suffered for year.
I have been on Imitrix and Maxalt, but have actually found that taking a combo of 6 mg ibuprofin and 3 mg Excedrin work better than either and it is safe to take that 3 times a week. I think that a preventative is also important.
I was taking Topamax a few years ago for Migraines. I must say I really did lose weight while taking Topamax and I felt great. After taking it about 3 months I noticed that I was becoming depressed. After doing some reading on my insurance carries website, I found that depression is a side effect of Topamax, otherwise it would have been great for me. If you don't have any problems GREAT because it WORKS VERY WELL!
I have been I topamax for 9 weeks and been taking 50 mg daily at night... at the begining of the treatment it did help me prevent the migraines but now it does not. By the time I get up, I wake up with a headache, so am afraid I need to go and see the the dr again.