Venlafaxine, also known by its trade name as Effexor, is an antidepressant. It is used for the treatment of major depressive disorder and anxiety disorders, and specifically for generalized anxiety disorder and social anxiety disorder. Physicians are becoming more likely to prescribe Effexor to treat other symptoms and conditions as well. Since Effexor works by regulating serotonin and norepinephrine levels in the brain, it can effectively help treat pain caused by severe migraines and diabetic neuropathy. This tablets is available on prescription only.
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While symptoms of depressed mood and lack of interest in activities may need up to 4-6 weeks to improve; disturbances in sleep, appetite or energy may show some improvement within the first 1-2 weeks. Improvement in these physical symptoms can be an important early signal that the medication is working.
Effexor comes in immediate-release tablets of 25 mg, 37.5 mg, 50 mg, 75 mg, and 100 mg, and in extended-release capsules of 37.5 mg, 75 mg, 150 mg, and 225 mg. If taken as an immediate-release pill, the dose is usually split up and taken two or three times during the day, with food. If you're taking the extended-release capsules, take your dose at breakfast or dinner, ideally at the same time every day. You need to swallow the capsule whole: do no crush, chew or place it in a liquid.
Trazodone (Desyrel) is an antidepressant of the serotonin antagonist and reuptake inhibitor class. It is a phenylpiperazine compound. Trazodone also has anti-anxiety and sleep-inducing effects. Its side-effect profile and potential toxicity are considerably different from those of the original antidepressants (i.e., the monoamine oxidase inhibitors and tricyclic antidepressants). It is available in multiple generic and brand versions. Generic trazodone is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
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Those with depression may begin to notice improvement in symptoms in 1-2 weeks, but in may take 4-6 weeks before the maximum benefit is reached. Some symptoms may improve before others do, and you may have good days and bad days for a few weeks - this is normal progress when recovering from depression.
Therapy is usually started at a total of 150 mg per day divided into two or three doses. This dose is increased by 50 mg every three or four days until the desired effects are seen. Daily doses may be increased to a maximum of 400 mg per day in outpatients and up to 600 mg per day in hospitalized patients. In cases of extreme depression, daily doses of up to 800 mg have been used in hospitalized patients.
My physician started me out on 37.5 mg/day for 1 week then increased the dosage to 75 mg/day for another week and, finally, to 150 mg/day. After taking 150 mg/day for about a week, I felt it was too much... my heart was always racing, I couldn't sleep, and I generally just felt "nervous". My physician dropped my dosage back to 75 mg/day and that seemed to work best for me. I absolutely feel that the Effexor helped lift my depression. However, I eventually chose to stop taking it because of the sexual side effects. After being on Effexor for about a year, I both wanted and needed to have a healthy sexual relationship with my husband again. I dropped the dosage back to 37.5 mg/day for a week, then one every other day for about another week before stopping altogether. I don't recall having any "withdrawal" symptoms. Within a few days of the last dose, all sexual functions were back.
Effexor helped me immensely with pulling out of a very long/recurrent depression. I think I started at 75mg, and had mild side effects that pretty much went away. Some people cant tolerate it at all, but if you can, it can be very effective. I maxed out at 450mg for something like 6 months and while it was great for my depression, it never helped with my anxiety problems. After my first several-days-long hypomanic episode though I'm rediagnosed bipolar ii and coming off effexor. And thats where most of the effexor horror stories start - a lot of us get withdrawal symptoms. I had no problems tapering back down to 150 but get "the zaps" and nausea etc below that. But there are ways to manage and reduce it. Overall, even though the med has some downsides, its definitely been a positive experience for me.
I was prescribed trazadone to help me sleep which it does but it has also helped me tremendously with my depression. This has been good for me. I am having a problem with interaction with Zoloft effecting my eyes. I am going to talk to my doctor about changing my antidepressant.
Trazodone works great for me. I actually only take 50 mg. And get a good 7-8 hours sleep. I'm a diagnosed insomniac. But Trazodone does the job.
I was taking regular Trazodone on and off for a couple of years, it stopped working so my doctor switched me to Desyrel. It's a good pill for the fact that it does make you tired, but I'd make sure you're gonna get 8 or more hours of sleep before you take it. I was prescribed 100mg pills, and I only took half of a pill whenever I took it, and I had the hardest time waking up the next day. Also, with the reg Trazodone and with Desyrel, it took a long time for it to kick in for me (2 hours), but that might be because I have a high tolerance to pills. If you're new to this medicine, take it on the weekend, or whenever you can sleep in, so you can see how it works.