Demadex (torsemide) is a loop diuretic (water pill) that prevents your body from absorbing too much salt, allowing the salt to instead be passed in your urine. Demadex treats fluid retention in people with congestive heart failure, liver disease, and kidney disorder. It also used to treat high blood pressure.
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Demadex acts from within the lumen of the thick ascending portion of the loop of Henle, where it inhibits the Na+/K+/2CI--carrier system. Effects in other segments of the nephron have not been demonstrated. Diuretic activity thus correlates better with the rate of drug excretion in the urine than with the concentration in the blood. Demadex increases the urinary excretion of sodium, chloride, and water, but it does not significantly alter glomerular filtration rate, renal plasma flow, or acid-base balance.
Congestive heart failure: the standard starting dose is 10 or 20 mg taken by mouth once per day. The maximum dose is 200 mg per day.
Kidney failure: The standard starting dose is 20 mg taken by mouth once per day. The maximum dose is 200 mg per day.
Liver disease: The standard starting dose is 5 or 10 mg taken by mouth once per day. The maximum dose is 40 mg per day.
Hypertension: The usual initial dose is 5 mg once daily. If the 5 mg dose does not provide adequate reduction in blood pressure within 4 to 6 weeks, the dose may be increased to 10 mg once daily.
Lasix (furosemide) is in a class of medications called diuretics or "water pills". It helps you make more urine and to lose salt and excess water from your body. This medicine is used to treat high blood pressure, and edema or swelling from heart, kidney or liver disease.
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In the kidneys, salt, water, and other small molecules normally are filtered out of the blood and into the tubules of the kidney. The filtered fluid ultimately becomes urine. Most of the sodium, chloride and water that is filtered out of the blood is reabsorbed into the blood before the filtered fluid becomes urine and is eliminated from the body. Lasix works by blocking the absorption of sodium, chloride, and water from the filtered fluid in the kidney tubules, causing a profound increase in the output of urine.
Your doctor will decide what dose you should take based on your condition and medical history. Never stop taking Lasix or alter your dose without your doctor's approval.
Adults who have fluid retention problems will typically begin with a single dose of 20 milligrams to 80 mg. The dose in children will vary based on what your doctor deems appropriate.
Adults who have high blood pressure often begin with 40 mg, twice per day. The dosage may be adjusted for elderly patients.
I had been using lasix 40mg for a couple of years to control my water retention BUT it caused my blood sodium levels to drop to critical level and put me in the hospital for 11 days, but I'm using demadex now and it works for me with no other problems.
I was prescribed with Demadex (torsemide) to treat my high blood pressure. I live with hypertension since I remember myself and it really affects my lifestyle and my career. With Demadex the quality of my life is much higher as I know that I take a drug that I can rely on and it won't give me up when I do not expect it. Demadex is a life saver for me and I thank the people who have invented this med!
My wife (52 years old) started furosemide 20 mg twice a day for fluid retention. It has helped with that, but has caused hearing loss in both ears. She has been told to stop for two weeks and see her doctor for blood work afterwards.
I have been taking Lasix for a long time due to hypertension. I have a lot of problems with swollen hands, especially in the mornings. I am very sensitive to salt. I have to be careful taking it when I am working because for the first few hours I am there, I usually have to go to the restroom several times, but then it levels off in the afternoon. I also started Wellbutrin which also has a diuretic effect, so taking both of them sometimes gets a little out of hand!
I have been using Lasix in combination with Hydrochlorothiazide for 6 months for pitting edema/hypertension and it's effects seem to have worn off. I started on 20mg once a day for 2 months then up to 40mg once a day for the last 4 months. Now my legs are back to swelling as much as if I were taking nothing. My blood pressure is good though. Side effects, headaches.