Arimidex (Anastrozole) is a prescription drug. It's used with other treatments, such as radiation or surgery, to treat early breast cancer in women who have experienced menopause (change of life; end of monthly menstrual periods).
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Anastrozole is an aromatase inhibitor. This means it blocks the enzyme aromatase (found in the skin, body's muscle, breast and fat), which is used to convert androgens (hormones produced by the adrenal glands) into estrogens. Tumor cells dependent on estrogens grow less when there is no estrogen.
The dose of Arimidex is one 1 mg pill taken once a day. For patients with advanced breast cancer, Arimidex should be continued until tumor progression.
Nolvadex (Tamoxifen) is used to treat breast cancer that has spread to other parts of the body in women and men. It is used to treat early breast cancer in women who have already been treated with surgery, chemotherapy and/or radiation.
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Many breast cancers rely on the hormone oestrogen to grow. This type of breast cancer is called oestrogen receptor-positive (ER positive) breast cancer. Tamoxifen blocks oestrogen from reaching the cancer cells. This means the cancer either grows more slowly or stops growing altogether.
For patients with breast cancer, the recommended daily dose is 20-40 mg. Dosages greater than 20 mg per day should be given in divided doses (morning and evening).
I have been taking Arimidex for 1.5 years. At first the only side affect I had was night sweats. Now I am wearing a wig as I have hair loss, my mouth is always dry, my eyes burn due to dry eyes, my knees hurt and I get weird sensations in my toes. Wondering if it is really helping enough to have these side effects.
I have been taking arimidex for 2 months. Within the first two weeks my osteoarthritis has deteriorated from tolerable to barely able to walk. I can not stand for long periods. My knees get stiff each time I sit. I have received a series if Ortho visc injections and am hoping for a miracle. I must keep working for insurance coverage. I have vision changes, chest and muscle pain,also. I have added fosamax due to the risk of calcium loss since I was diagnosed with osteopenia at the same time as stage 1 breast cancer. I am expertiencing more fatigue with arimidex than after radiation. I am not sure if I can tough this out for five years!
Many hot flashes, but was having them anyway from the chemo. Knowing that Tamoxifen has worked on many in the past makes me confident that what I'm doing is a good thing.
I was on Tamoxifen for 5 years when I was 41 with very little side effects, or so I thought at the time. Its now that I look back that I do have a problem with mental clarity, confusion and memory loss. Does anyone know if this will improve now I have been off tamoxifen for 2 years. Although my consultant is talking about going back on it for another 5 years.
I was initially diagnosed at age 43 and refused Tamoxifen. I was diagnosed again last year and started Tamoxifen the day after my biopsy. Initially I was dizzy but that is long gone. I take it at night and have mild hot flashes. My period id fairly regular (I'm 48 now) but very light. I have put on 10 pounds. All in all, not a bad ride!